Combinatorial chemistry (or Combi-Chem) is an innovative method of synthesizing many different substances quickly and at the same time. Combinatorial chemistry contrasts with the time-consuming and labor intensive methods of traditional chemistry where compounds are synthesized individually, one at a time Combinatorial chemistry was developed to produce the large numbers of compounds required for high throughput screening. It allows the simultaneous synthesis of a large number of the possible compounds that could be formed from a number of building blocks. The products of such a process are known as a combinatorial library. Libraries may be a collection of individual compounds or mixtures of compounds. Screening the components of a library for activity using high throughput screening techniques enables the development team to select suitable compounds for a more detailed investigation by either combinatorial chemistry or other methods. Different methods of combi chemistry are solid phase, solution phase synthesis, parallel method and biological methods.
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